Senior high school student Macin Smith doesn't come home from school September 1st, 2015 and his parents are left to worry about the safety of the youngest of their six children and what has happened to him.

Twenty-one year-old Kortne Stouffer vanishes from her bed one night following a couple of scuffles with neighbors and friends. Investigators pursue various leads, but the young beauty is nowhere to be found, and her family clings to an endless hope.

Elizabeth Salgado is the beautiful young lady who disappeared.

College sophomore Martin Roberts is a popular fraternity brother, suddenly he goes missing. The only clue he leaves: a cryptic note. Baffling secrets emerge. But two years later, his family remains desperate to know what has happened to him.

When 70-year-old retired firefighter Michael Chambers goes missing, a bloody crime scene in his garage quickly indicates foul play. But authorities begin to believe that the crime scene may have been staged and that Michael may have left on his own.

Nancy Moyer isn't home when her kids come back from visiting their dad. Police look into her background, and find a more complicated life than anyone knows. But when a random murder occurs nearby, the question becomes could the cases be connected?

Lynn Messer, a wife, mother, and bible teacher, goes missing from the family's cattle farm near St. Genevieve Missouri. Her two sons, two sisters, the local sheriff, a chief detective, and the whole community, search desperately for over two years to find her. But then there is an unexpected and huge break in the case.

20-year old Bear Diaz has diabetes, leaving him weak and vulnerable. When he vanishes in the night with his TV, backpack and cash, investigators must consider foul play. Then Skylar Tosic disappears, leaving people wondering if the cases are linked.

After a night at home watching movies, 18-year-old Zoe Campos cannot be found by her family the next morning. As investigators pore through the teen's Facebook account, they discover she did not turn in early as her loved ones originally thought.

On route to the airport, nineteen-year-old Katelin Akens makes an unexpected stop at a Virginia shopping mall...and vanishes. Police investigate her loved ones at length and start to suspect that someone close to Katelin may know more than they're saying.

In the middle of the night at his home in Clearwater, Florida, eight-year-old Zachary Bernhardt disappears. His mother was taking a quick late night dip in their apartment's pool, then went to check on him but found that he wasn't in his bed. There is no sign of a break in or struggle, and suspicions swirl around the single mother, who denies any involvement in her son's disappearance and ends up moving away. But when another boy goes missing from the area, new theories emerge as the quiet beach town is gripped by fear. After sixteen years of not knowing what happened, Zachary's family and local law enforcement continues to search for answers.

Eric Lee Franks 38 from Saginaw Michigan moved to Ohio in 2013 to meet the teenage daughter he didn't know about, 6 months later his mother in Michigan reported him missing.

When 15-yr-old Kayla Berg isn't home after a night out, her loved ones believe she's staying with friends. But when six days pass and the aspiring gymnast is missing, the details of her last known whereabouts raise suspicion in a close-knit town.

A date night in Philadelphia becomes deeply disturbing when a couple disappears. Their families unite to find them, but as desperation grows, finger pointing puts them at odds. Soon, the FBI takes over the investigation that is riddled with speculation.

19-year-old Angel Garcia disappears after riding his dirt bike around Hartford CT. Friends say Angel was chased by a mysterious SUV before he disappeared. Months Later, a possible sighting in a convenience store 15 miles from home. Could it be Angel?

Deanne Hastings, a 35-year-old Spokane mom, leaves a note that she's running to the store, but she never returns. As detectives uncover more information about Deanne's actions leading up to her disappearance, a slew of troubling theories emerge.

Ashley Summers is a fun-loving 14-year-old. When she vanishes on July 4th, her family is at a loss. The mystery deepens when the FBI connects her case to two other young women missing from her neighborhood.Ten years later, there's still no answer.